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  • NYU Dataset

    RNA Recognition Mechanism that Governs Np4 Decapping by RppH

    Authors
    Rose Levenson-Palmer
    Daniel J. Luciano
    Nikita Vasilyev
    Ashok Nuthanakanti
    2 more author(s)...
    Description

    Dinucleoside tetraphosphates have been shown to function in bacteria as precursors to nucleoside tetraphosphate (Np4) RNA caps. The removal of this cap is critical for initiating 5′ end-dependent degradation of those RNAs, which affects bacterial adaptability to stress. This study described that the RNA pyrophosphohydrolase (RppH) assumes a leading role in decapping those transcripts in Escherichia...

    Subject
    Cell Physiology
    Access Rights
    Free to All
  • NYU Dataset

    An eIF3d-Dependent Switch Regulates Human Cytomegalovirus Replication

    Authors
    Letitia Thompson
    Daniel P. Depledge
    Hannah M. Burgess
    Ian Mohr
    Description

    Gene expression rapidly responds to physiological stress like virus infection in part via the control of mRNA translation. However, how translation of virus and host mRNAs are regulated during infection stress remains unknown. This study showed that protein synthesis in human cytomegalovirus (HCMV)-infected cells unexpectedly becomes progressively reliant upon eIF3d, which is a mRNA cap-binding protein...

    Subject
    Genomics
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    Free to All